Chemicals and Drugs

Orphan Nuclear Receptors

A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • Orphan Nuclear Receptor
  • Nuclear Receptor, Orphan
  • Nuclear Receptors, Orphan
  • Receptor, Orphan Nuclear
  • Receptors, Orphan Nuclear

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not confuse with RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS

MeSH Record

History Note

2010

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Orphan Nuclear Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D057093. http://id.nlm.nih.gov/mesh/2026/D057093
  2. Orphan Nuclear Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Orphan_receptor
  3. Orphan Nuclear Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q2496179