Chemicals and Drugs

Receptors, Cytoplasmic and Nuclear

Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

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Classification

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See Also

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Synonyms

27 entry terms
  • Cytoplasmic and Nuclear Receptors
  • Cytosol and Nuclear Receptors
  • Cytosolic and Nuclear Receptors
  • Nuclear and Cytoplasmic Receptors
  • Receptors, Cytosol and Nuclear
  • Receptors, Cytosolic and Nuclear
  • Receptors, Nuclear and Cytoplasmic
  • Cytoplasmic Hormone Receptors
  • Cytoplasmic Receptor
  • Cytoplasmic Receptors
  • Hormone Receptors, Cytoplasmic
  • Hormone Receptors, Nuclear
  • Intracellular Membrane Receptors
  • Nuclear Hormone Receptor
  • Nuclear Hormone Receptors
  • Nuclear Receptor
  • Nuclear Receptors
  • Receptors, Cytoplasmic
  • Receptors, Intracellular Membrane
  • Receptors, Nuclear
  • Hormone Receptor, Nuclear
  • Membrane Receptors, Intracellular
  • Receptor, Cytoplasmic
  • Receptor, Nuclear
  • Receptor, Nuclear Hormone
  • Receptors, Cytoplasmic Hormone
  • Receptors, Nuclear Hormone

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

general or unspecified; prefer specifics; for hormone receptors, see note at RECEPTORS, CELL SURFACE

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History Note

94

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Previous Indexing

  • Receptors, Cell Surface (1983-1993)

MeSH Hierarchy

Tree Number

MeSH Record

NLM Classification

QU 55.2

AMA Style

References

  1. National Library of Medicine. Receptors, Cytoplasmic and Nuclear. Medical Subject Headings (MeSH). 2026. Unique ID D018160. http://id.nlm.nih.gov/mesh/2026/D018160
  2. Receptors, Cytoplasmic and Nuclear. In: Wikipedia. https://en.wikipedia.org/wiki/Intracellular_receptor
  3. Receptors, Cytoplasmic and Nuclear. In: Wikidata. https://www.wikidata.org/wiki/Q117980