Chemicals and Drugs

Group F Member 1 Nuclear Receptor Subfamily 1

A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A DNA-binding orphan nuclear receptor that positively regulates expression of ARNTL TRANSCRIPTION FACTORS and is a regulatory component of the circadian clock system. The protein also has a role in neuron cell survival and differentiation in that loss of function mutations of its gene result in the mouse phenotype referred to as the STAGGERER MOUSE.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

21 entry terms
  • Nuclear Receptor NR1F1
  • Nuclear Receptor ROR-alpha
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • RAR-Related Orphan Receptor A
  • Retinoid-Related Orphan Receptor-alpha
  • NR1F1, Nuclear Receptor
  • Nuclear Receptor ROR alpha
  • RAR Related Orphan Receptor A
  • Receptor NR1F1, Nuclear
  • Retinoid Related Orphan Receptor alpha
  • Nuclear Receptor RZR-alpha
  • Retinoid-Related Orphan Receptor-alpha1
  • Retinoid-Related Orphan Receptor-alpha2
  • Retinoid-Related Orphan Receptor-alpha3
  • Retinoid-Related Orphan Receptor-alpha4
  • Nuclear Receptor RZR alpha
  • RZR-alpha, Nuclear Receptor
  • Retinoid Related Orphan Receptor alpha1
  • Retinoid Related Orphan Receptor alpha2
  • Retinoid Related Orphan Receptor alpha3
  • Retinoid Related Orphan Receptor alpha4

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2010(1996)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.643w.100
  2. D12.776w.476.156.437
  3. D12.776w.826w.209w.100

AMA Style

References

  1. National Library of Medicine. Group F Member 1 Nuclear Receptor Subfamily 1. Medical Subject Headings (MeSH). 2026. Unique ID D057094. http://id.nlm.nih.gov/mesh/2026/D057094
  2. Group F Member 1 Nuclear Receptor Subfamily 1. In: Wikidata. https://www.wikidata.org/wiki/Q78114734