Structured Summary
Abstract
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
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Classification
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See Also
- Janus Kinase 1
- Janus Kinase 2
- Janus Kinase 3
- Janus Kinases
- Non-Receptor Type 6 Protein Tyrosine Phosphatase
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins c-vav
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- src Genes
- src-Family Kinases
- STAT1 Transcription Factor
- STAT3 Transcription Factor
- Syk Kinase
- TYK2 Kinase
- ZAP-70 Protein-Tyrosine Kinase
MeSH Record
Synonyms
12 entry terms
- SH Domains
- Homology Domain, src
- Homology Domains, src
- SH Domain
- src Homology Domain
- SH1 Domain
- SH2 Domain
- SH3 Domain
- src Homology Region 2 Domain
- SH1 Domains
- SH2 Domains
- SH3 Domains
MeSH Record
Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
MeSH Record
History Note
96
MeSH Record
Previous Indexing
- Amino Acid Sequence (1989-1995)
- Sequence Homology, Amino Acid (1993-1995)
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AMA Style
References
- National Library of Medicine. src Homology Domains. Medical Subject Headings (MeSH). 2026. Unique ID D018909. http://id.nlm.nih.gov/mesh/2026/D018909
- src Homology Domains. In: Wikipedia. https://en.wikipedia.org/wiki/Src_homology_domain
- src Homology Domains. In: Wikidata. https://www.wikidata.org/wiki/Q7582407