Structured Summary
Abstract
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
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Synonyms
14 entry terms
- DNA Topoisomerase (ATP-Hydrolysing)
- DNA Topoisomerase II
- DNA Topoisomerases, Type II
- DNA Type 2 Topoisomerase
- Topoisomerase II
- Type II DNA Topoisomerase
- DNA Topoisomerase II alpha
- DNA Topoisomerase II beta
- TOP2A Protein
- TOP2B Protein
- Topoisomerase II alpha
- Topoisomerase II beta
- alpha, Topoisomerase II
- beta, Topoisomerase II
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018(2002); use DNA GYRASE 1980-1993
MeSH Record
Previous Indexing
- DNA (1966-1977)
- DNA Replication (1968-1979)
- DNA Untwisting Proteins (1978-1979)
- DNA, Superhelical (1978-1979)
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AMA Style
References
- National Library of Medicine. Type II DNA Topoisomerases. Medical Subject Headings (MeSH). 2026. Unique ID D004250. http://id.nlm.nih.gov/mesh/2026/D004250
- Type II DNA Topoisomerases. In: Wikipedia. https://en.wikipedia.org/wiki/Type_II_topoisomerase
- Type II DNA Topoisomerases. In: Wikidata. https://www.wikidata.org/wiki/Q411991