Structured Summary
Abstract
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
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Classification
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Synonyms
11 entry terms
- Topo IV
- Topoisomerase IV
- Topoisomerase IV, DNA
- Topoisomerase IV Subunit A
- Topoisomerase IV Subunit B
- parC Gene Product
- parC Gene Product, Topo IV
- parC Protein
- parE Gene Product
- parE Gene Product, Topo IV
- parE Protein
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2002; use DNA TOPOISOMERASE IV (NM) 1991-2001
MeSH Record
Previous Indexing
- DNA Topoisomerase (1990-1995)
- DNA Topoisomerase (ATP-Hydrolysing) (1991-2001)
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AMA Style
References
- National Library of Medicine. DNA Topoisomerase IV. Medical Subject Headings (MeSH). 2026. Unique ID D027101. http://id.nlm.nih.gov/mesh/2026/D027101
- DNA Topoisomerase IV. In: Wikidata. https://www.wikidata.org/wiki/Q77044917