Structured Summary
Abstract
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
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Classification
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Synonyms
5 entry terms
- DNA-Gyrase
- DNA Gyrase A Subunit
- DNA Gyrase B Subunit
- GyrA Protein
- GyrB Protein
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2002; use DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, use DNA GYRASE 1980-1993; for GYRA PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001
MeSH Record
Previous Indexing
- DNA Topoisomerases (1977-1978)
- DNA Topoisomerases, Type II (1979-2001)
- DNA, Circular (1976-1977)
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AMA Style
References
- National Library of Medicine. DNA Gyrase. Medical Subject Headings (MeSH). 2026. Unique ID D027081. http://id.nlm.nih.gov/mesh/2026/D027081
- DNA Gyrase. In: Wikipedia. https://en.wikipedia.org/wiki/DNA_gyrase
- DNA Gyrase. In: Wikidata. https://www.wikidata.org/wiki/Q70551687