Chemicals and Drugs

Monoclonal Humanized Antibodies

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

3 entry terms
  • Antibodies, Humanized
  • Antibodies, Monoclonal, Humanized
  • Humanized Antibodies

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2012

MeSH Record

Previous Indexing

  • Antibodies, Monoclonal (1991-2011)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.224w.060w
  2. D12.776w.124w.790.651.114w.224w.060w
  3. D12.776w.377w.715.548.114w.224w.200w

AMA Style

References

  1. National Library of Medicine. Monoclonal Humanized Antibodies. Medical Subject Headings (MeSH). 2026. Unique ID D061067. http://id.nlm.nih.gov/mesh/2026/D061067
  2. Monoclonal Humanized Antibodies. In: Wikipedia. https://en.wikipedia.org/wiki/Humanized_antibody
  3. Monoclonal Humanized Antibodies. In: Wikidata. https://www.wikidata.org/wiki/Q5939625