Chemicals and Drugs

Certolizumab Pegol

A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A polyethylene-glycolated Fab' fragment of TUMOR NECROSIS FACTOR antibody that binds specifically to TNF-ALPHA and neutralises it in a dose-dependent manner. It also inhibits the production of lipopolysaccharide-induced TNF-ALPHA and IL-1 BETA and is used to treat RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

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See Also

MeSH Record

Synonyms

3 entry terms
  • CDP 870
  • CDP870
  • Cimzia

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016 (2003)

MeSH Hierarchy

Tree Numbers

  1. D05.750w.741w.125w
  2. D12.644w.541.500.650w.250w
  3. D12.776w.124w.486.485.114w.224w.060w.500w
  4. D12.776w.124w.486.485.680.650w.250w
  5. D12.776w.124w.790.651.114w.224w.060w.500w
  6. D12.776w.124w.790.651.680.650w.250w
  7. D12.776w.377w.715.548.114w.224w.200w.500w
  8. D12.776w.377w.715.548.680.650w.250w

AMA Style

References

  1. National Library of Medicine. Certolizumab Pegol. Medical Subject Headings (MeSH). 2026. Unique ID D000068582. http://id.nlm.nih.gov/mesh/2026/D000068582
  2. Certolizumab Pegol. In: Wikipedia. https://en.wikipedia.org/wiki/Certolizumab_pegol
  3. Certolizumab Pegol. In: Wikidata. https://www.wikidata.org/wiki/Q412909