Chemicals and Drugs

Denosumab

A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

3 entry terms
  • AMG 162
  • Prolia
  • Xgeva

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2016 (2004)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.224w.060w.782w
  2. D12.776w.124w.790.651.114w.224w.060w.782w
  3. D12.776w.377w.715.548.114w.224w.200w.782w

AMA Style

References

  1. National Library of Medicine. Denosumab. Medical Subject Headings (MeSH). 2026. Unique ID D000069448. http://id.nlm.nih.gov/mesh/2026/D000069448
  2. Denosumab. In: Wikipedia. https://en.wikipedia.org/wiki/Denosumab
  3. Denosumab. In: Wikidata. https://www.wikidata.org/wiki/Q408283