Chemicals and Drugs

Estradiol

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

Chemical Identity

Chemical Information

Molecular Formula
C18H24O2
Molecular Weight
272.4 g/mol
CAS Registry No.
50-28-2
IUPAC Name
(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
MeSH Unique ID
D004958
Source
PubChem CID 5757

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

37 entry terms
  • 17 beta-Estradiol
  • 17 beta-Oestradiol
  • Estradiol Anhydrous
  • Estradiol-17 beta
  • Estradiol-17beta
  • Oestradiol
  • 17 beta Estradiol
  • 17 beta Oestradiol
  • Estradiol 17 beta
  • Estradiol 17beta
  • Aerodiol
  • Delestrogen
  • Estrace
  • Estraderm TTS
  • Estradiol Hemihydrate
  • Estradiol Hemihydrate, (17 alpha)-Isomer
  • Estradiol Monohydrate
  • Estradiol Valerate
  • Estradiol Valeriante
  • Estradiol, (+-)-Isomer
  • Estradiol, (-)-Isomer
  • Estradiol, (16 alpha,17 alpha)-Isomer
  • Estradiol, (16 alpha,17 beta)-Isomer
  • Estradiol, (17-alpha)-Isomer
  • Estradiol, (8 alpha,17 beta)-(+-)-Isomer
  • Estradiol, (8 alpha,17 beta)-Isomer
  • Estradiol, (9 beta,17 alpha)-Isomer
  • Estradiol, (9 beta,17 beta)-Isomer
  • Estradiol, Monosodium Salt
  • Estradiol, Sodium Salt
  • Estradiol-17 alpha
  • Ovocyclin
  • Progynon-Depot
  • Progynova
  • Vivelle
  • Estradiol 17 alpha
  • Progynon Depot

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

for /antag also consider: ESTROGEN RECEPTOR MODULATORS; ESTROGEN RECEPTOR ANTAGONISTS; and AROMATASE INHIBITORS.

MeSH Record

History Note

1963; for OVOCYCLIN use ESTRADIOL DIPROPIONATE (NM) 1980-1998; /therapeutic use was ESTRADIOL, THERAPEUTIC 1965

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.365.415.248w
  2. D06.472w.334.851w.437.500w

MeSH Record

NLM Classification

WP 522

AMA Style

References

  1. National Library of Medicine. Estradiol. Medical Subject Headings (MeSH). 2026. Unique ID D004958. http://id.nlm.nih.gov/mesh/2026/D004958
  2. Estradiol. In: Wikipedia. https://en.wikipedia.org/wiki/Estradiol
  3. Estradiol. In: Wikidata. https://www.wikidata.org/wiki/Q422416
  4. Estradiol. In: PubChem Compound. CID 5757. https://pubchem.ncbi.nlm.nih.gov/compound/5757