Chemicals and Drugs

2-Methoxyestradiol

A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. It has antineoplastic properties, including inhibition of angiogenesis and induction of APOPTOSIS.

Chemical Identity

Chemical Information

Molecular Formula
C19H26O3
Molecular Weight
302.4 g/mol
CAS Registry No.
362-07-2
IUPAC Name
(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChIKey
CQOQDQWUFQDJMK-SSTWWWIQSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O
MeSH Unique ID
D000077584
Source
PubChem CID 66414

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • (17 beta)-2-methoxyestra-1,3,5(10)-triene-3,17-diol
  • 2-Methoxyoestradiol
  • 2 Methoxyestradiol
  • 2 Methoxyoestradiol
  • 2-(methyl-11C)Methoxyestradiol
  • 2-Methoxyestradiol, (17alpha)-isomer
  • 2-Methoxyestradiol-17 beta
  • Panzem
  • 2 Methoxyestradiol 17 beta

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1980)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.365.415.248w.830w
  2. D06.472w.334.851w.437.500w.750w

AMA Style

References

  1. National Library of Medicine. 2-Methoxyestradiol. Medical Subject Headings (MeSH). 2026. Unique ID D000077584. http://id.nlm.nih.gov/mesh/2026/D000077584
  2. 2-Methoxyestradiol. In: Wikipedia. https://en.wikipedia.org/wiki/2-Methoxyestradiol
  3. 2-Methoxyestradiol. In: Wikidata. https://www.wikidata.org/wiki/Q4596897
  4. 2-Methoxyestradiol. In: PubChem Compound. CID 66414. https://pubchem.ncbi.nlm.nih.gov/compound/66414