Structured Summary
Abstract
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Chemical Identity
Chemical Information
- Molecular Formula
- C23H31Cl2NO3
- Molecular Weight
- 440.4 g/mol
- CAS Registry No.
- 2998-57-4
- IUPAC Name
- [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate
- InChIKey
- FRPJXPJMRWBBIH-RBRWEJTLSA-N
- SMILES
- C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
- MeSH Unique ID
- D004961
- Source
- PubChem CID 259331
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
13 entry terms
- Emcyt
- Estracyt
- Estramustin Phosphate
- Estramustine Phosphate Sodium
- Estramustinphosphate
- Leo-275
- NSC-89199
- Leo 275
- Leo275
- NSC 89199
- NSC89199
- Phosphate Sodium, Estramustine
- Phosphate, Estramustin
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
91(80); was see under NITROGEN MUSTARD COMPOUNDS 1980-90; was ESTRAMUSTINPHOSPHATE see under NITROGEN MUSTARD COMPOUNDS 1975-79
MeSH Record
Previous Indexing
- Carbamates (1972-1974)
- Estranes (1972-1974)
- Nitrogen Mustard Compounds (1972-1974)
- Organophosphorus Compounds (1973-1974)
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QV 269
AMA Style
References
- National Library of Medicine. Estramustine. Medical Subject Headings (MeSH). 2026. Unique ID D004961. http://id.nlm.nih.gov/mesh/2026/D004961
- Estramustine. In: Wikipedia. https://en.wikipedia.org/wiki/Estramustine
- Estramustine. In: Wikidata. https://www.wikidata.org/wiki/Q412939
- Estramustine. In: PubChem Compound. CID 259331. https://pubchem.ncbi.nlm.nih.gov/compound/259331