Chemicals and Drugs

Fulvestrant

An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.

Chemical Identity

Chemical Information

Molecular Formula
C32H47F5O3S
Molecular Weight
606.8 g/mol
CAS Registry No.
129453-61-8
IUPAC Name
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChIKey
VWUXBMIQPBEWFH-WCCTWKNTSA-N
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
MeSH Unique ID
D000077267
Source
PubChem CID 104741

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol
  • Faslodex
  • ICI 182,780
  • ICI 182780
  • ICI-182780
  • ZM 182780
  • ZM-182780
  • ICI182780
  • ZM182780

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1991)

MeSH Hierarchy

Tree Numbers

  1. D04w.210.500w.365.415.248w.660w
  2. D06.472w.334.851w.437.500w.500w

AMA Style

References

  1. National Library of Medicine. Fulvestrant. Medical Subject Headings (MeSH). 2026. Unique ID D000077267. http://id.nlm.nih.gov/mesh/2026/D000077267
  2. Fulvestrant. In: Wikipedia. https://en.wikipedia.org/wiki/Fulvestrant
  3. Fulvestrant. In: Wikidata. https://www.wikidata.org/wiki/Q5508491
  4. Fulvestrant. In: PubChem Compound. CID 104741. https://pubchem.ncbi.nlm.nih.gov/compound/104741