Structured Summary
Abstract
A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
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Synonyms
17 entry terms
- Classic Apoptosis
- Classical Apoptosis
- Programmed Cell Death, Type I
- Apoptosis, Classic
- Apoptosis, Classical
- Classic Apoptoses
- Apoptosis, Extrinsic Pathway
- Apoptosis, Intrinsic Pathway
- Caspase-Dependent Apoptosis
- Apoptoses, Extrinsic Pathway
- Apoptoses, Intrinsic Pathway
- Apoptosis, Caspase-Dependent
- Caspase Dependent Apoptosis
- Extrinsic Pathway Apoptoses
- Extrinsic Pathway Apoptosis
- Intrinsic Pathway Apoptoses
- Intrinsic Pathway Apoptosis
MeSH Record
Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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Indexing Annotation
general or unspecified, note specifics
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History Note
93
MeSH Record
Previous Indexing
- Cell Survival (1972-1992)
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NLM Classification
QU 375
AMA Style
References
- National Library of Medicine. Apoptosis. Medical Subject Headings (MeSH). 2026. Unique ID D017209. http://id.nlm.nih.gov/mesh/2026/D017209
- Apoptosis. In: Wikipedia. https://en.wikipedia.org/wiki/Apoptosis
- Apoptosis. In: Wikidata. https://www.wikidata.org/wiki/Q14599311