Structured Summary
Abstract
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
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Synonyms
12 entry terms
- In Situ Nick End Labeling
- In Situ Nick End Labelling
- In Situ Nick End-Labeling
- In Situ Nick End-Labelling
- In Situ Nick-End Labelling
- Nick End-Labeling, In Situ
- Nick End-Labelling, In Situ
- Nick-End Labeling, In Situ
- Nick-End Labelling, In Situ
- TUNEL
- Nick End Labeling, In Situ
- Nick End Labelling, In Situ
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10 allowable subheadings
Indexed with the subheadings classification, economics, ethics, history, instrumentation, methods, standards, statistics & numerical data, trends, veterinary.
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History Note
1999
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Previous Indexing
- Apoptosis (1994-1998)
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AMA Style
References
- National Library of Medicine. In Situ Nick-End Labeling. Medical Subject Headings (MeSH). 2026. Unique ID D020287. http://id.nlm.nih.gov/mesh/2026/D020287
- In Situ Nick-End Labeling. In: Wikipedia. https://en.wikipedia.org/wiki/TUNEL_assay
- In Situ Nick-End Labeling. In: Wikidata. https://www.wikidata.org/wiki/Q1624817