Structured Summary
Abstract
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
Drag nodes to rearrange; hover to trace links; click a node to open its page.
MeSH Record
See Also
MeSH Record
Synonyms
21 entry terms
- CASP1 Caspase
- ICE Protease
- IL-1 beta Convertase
- IL-1 beta-Converting Enzyme
- IL1BC Enzyme
- Interleukin-1 Converting Enzyme
- Interleukin-1beta Converting Enzyme
- Caspase, CASP1
- Convertase, IL-1 beta
- Converting Enzyme, Interleukin-1
- Converting Enzyme, Interleukin-1beta
- IL 1 beta Convertase
- IL 1 beta Converting Enzyme
- Interleukin 1 Converting Enzyme
- Interleukin 1beta Converting Enzyme
- beta Convertase, IL-1
- beta-Converting Enzyme, IL-1
- Pro-Caspase-1
- Procaspase-1
- Pro Caspase 1
- Procaspase 1
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
1999; use CASPASE 1 (NM) 1989-1998
MeSH Record
Previous Indexing
- Cysteine Proteinases (1995-1998)
- Metalloproteinases (1989-1994)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Caspase 1. Medical Subject Headings (MeSH). 2026. Unique ID D020170. http://id.nlm.nih.gov/mesh/2026/D020170
- Caspase 1. In: Wikidata. https://www.wikidata.org/wiki/Q5049052