Structured Summary
Abstract
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
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Synonyms
1 entry terms
- Superantigen
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Aspects Covered
23 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
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History Note
94
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Previous Indexing
- specific antigens (1989-1993)
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NLM Classification
QW 573
AMA Style
References
- National Library of Medicine. Superantigens. Medical Subject Headings (MeSH). 2026. Unique ID D018089. http://id.nlm.nih.gov/mesh/2026/D018089
- Superantigens. In: Wikipedia. https://en.wikipedia.org/wiki/Superantigen
- Superantigens. In: Wikidata. https://www.wikidata.org/wiki/Q772950