Chemicals and Drugs

Acute-Phase Proteins

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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MeSH Record

Synonyms

21 entry terms
  • Acute Phase Reactant
  • Acute-Phase Protein
  • Acute-Phase Reactant
  • Acute-Phase Reactants
  • Proteins, Acute-Phase
  • Reactants, Acute-Phase
  • Acute Phase Protein
  • Acute Phase Proteins
  • Acute Phase Reactants
  • Phase Reactant, Acute
  • Protein, Acute-Phase
  • Proteins, Acute Phase
  • Reactant, Acute Phase
  • Reactant, Acute-Phase
  • Reactants, Acute Phase
  • Acute-Phase Glycoprotein
  • Acute-Phase Glycoproteins
  • Acute Phase Glycoprotein
  • Acute Phase Glycoproteins
  • Glycoprotein, Acute-Phase
  • Glycoproteins, Acute-Phase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

blood proteins; /biosyn /drug eff /physiol permitted

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Blood Proteins (1966-1986)
  • C-Reactive Protein (1966-1986)
  • Glycoproteins (1966-1986)

MeSH Hierarchy

Tree Number

  1. D12.776w.124w.050w

MeSH Record

NLM Classification

WH 400

AMA Style

References

  1. National Library of Medicine. Acute-Phase Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D000209. http://id.nlm.nih.gov/mesh/2026/D000209
  2. Acute-Phase Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Acute-phase_protein
  3. Acute-Phase Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q424211