Chemicals and Drugs

alpha-Macroglobulins

Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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MeSH Record

Synonyms

26 entry terms
  • 45S RNP
  • alpha-Macrofetoproteins
  • RNP, 45S
  • alpha Macrofetoproteins
  • alpha Macroglobulins
  • Acute-Phase alpha 1-Protein
  • Slow alpha 2-Globulin
  • Slow alpha 2-Macroglobulins
  • alpha 1-Acute Phase Globulin
  • alpha 1-Acute Phase Protein
  • alpha 1-Macroglobulin
  • alpha 2-Acute Phase Globulin
  • alpha 2-Acute Phase Globulins
  • alpha-Macrofetoprotein
  • Acute Phase alpha 1 Protein
  • Slow alpha 2 Globulin
  • Slow alpha 2 Macroglobulins
  • alpha 1 Acute Phase Globulin
  • alpha 1 Acute Phase Protein
  • alpha 1 Macroglobulin
  • alpha 1-Protein, Acute-Phase
  • alpha 2 Acute Phase Globulin
  • alpha 2 Acute Phase Globulins
  • alpha 2-Globulin, Slow
  • alpha 2-Macroglobulins, Slow
  • alpha Macrofetoprotein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

96; was ALPHA MACROGLOBULINS 1976-95

MeSH Record

Previous Indexing

  • Macroglobulins (1973-1975)
  • alpha Globulins (1974-1975)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.050w.080
  2. D12.776w.124w.790.106w.100
  3. D12.776w.124w.790.720w.100
  4. D12.776w.377w.715.085w.100
  5. D12.776w.377w.715.647w.100

AMA Style

References

  1. National Library of Medicine. alpha-Macroglobulins. Medical Subject Headings (MeSH). 2026. Unique ID D000511. http://id.nlm.nih.gov/mesh/2026/D000511
  2. alpha-Macroglobulins. In: Wikidata. https://www.wikidata.org/wiki/Q58622554