Chemicals and Drugs

Kazal Pancreatic Trypsin Inhibitor

A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A secreted KAZAL MOTIF-containing serine peptidase inhibitor that inhibits TRYPSIN. It is a protein composed of 56 amino acid residues and is different in amino acid composition and physiological activity from the Kunitz bovine pancreatic trypsin inhibitor (APROTININ). It protects against the trypsin-mediated premature activation of ENZYME PRECURSORS in the PANCREAS. Mutations in the SPINK1 gene are associated with CHRONIC PANCREATITIS.

MeSH Record

Classification

Broader headings

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See Also

MeSH Record

Synonyms

17 entry terms
  • Acidic Pancreatic Trypsin Inhibitor
  • Inhibitor, Tumor-Associated Trypsin
  • Pancreatic Secretory Trypsin Inhibitor
  • Pancreatic Secretory Trypsin Inhibitor, Kazal
  • Pancreatic Trypsin Secretory Inhibitor, Kazal
  • SPINK1
  • Serine Peptidase Inhibitor, Kazal-Type 1
  • Serine Protease Inhibitor Kazal-Type 1
  • Trypsin Inhibitor Kazal Pancreatic
  • Trypsin Inhibitor, Kazal Pancreatic
  • Trypsin Inhibitor, Pancreatic Secretory
  • Trypsin Inhibitor, Tumor-Associated
  • Tumor-Associated Trypsin Inhibitor
  • Serine Peptidase Inhibitor, Kazal Type 1
  • Serine Protease Inhibitor Kazal Type 1
  • Trypsin Inhibitor, Tumor Associated
  • Tumor Associated Trypsin Inhibitor

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(75); was see under TRYPSIN INHIBITORS 1975-90

MeSH Record

Previous Indexing

  • Pancreatic Juice (1972-1974)
  • Trypsin Inhibitors (1972-1974)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.822.750.500
  2. D12.776w.124w.050w.850
  3. D12.776w.815.688.500

AMA Style

References

  1. National Library of Medicine. Kazal Pancreatic Trypsin Inhibitor. Medical Subject Headings (MeSH). 2026. Unique ID D014359. http://id.nlm.nih.gov/mesh/2026/D014359
  2. Kazal Pancreatic Trypsin Inhibitor. In: Wikidata. https://www.wikidata.org/wiki/Q78139405