Chemicals and Drugs

alpha 1-Antichymotrypsin

Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.

MeSH Record

Classification

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

3 entry terms
  • Serpin A3
  • alpha(1)-Antichymotrypsin
  • alpha 1 Antichymotrypsin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

87

MeSH Record

Previous Indexing

  • Chymotrypsin/antagonists & inhibitors (1968-1986)
  • Glycoproteins (1966-1986)
  • Protease Inhibitors (1979-1986)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. alpha 1-Antichymotrypsin. Medical Subject Headings (MeSH). 2026. Unique ID D000514. http://id.nlm.nih.gov/mesh/2026/D000514
  2. alpha 1-Antichymotrypsin. In: Wikidata. https://www.wikidata.org/wiki/Q21148036