Structured Summary
Abstract
A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.
MeSH Record
Classification
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- TIMP Proteins
- Tissue Inhibitor of Metalloproteinase
- Metalloproteinase Tissue Inhibitor
- Metalloproteinases Tissue Inhibitor
- Proteins, TIMP
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
general or unspecified; prefer specifics
MeSH Record
History Note
98; see TISSUE INHIBITOR OF METALLOPROTEINASES (NM) 1980-97
MeSH Record
Previous Indexing
- Enzyme Inhibitors (1989-1997)
- Glycoproteins (1980-1990)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Tissue Inhibitor of Metalloproteinases. Medical Subject Headings (MeSH). 2026. Unique ID D019714. http://id.nlm.nih.gov/mesh/2026/D019714
- Tissue Inhibitor of Metalloproteinases. In: Wikipedia. https://en.wikipedia.org/wiki/Tissue_inhibitor_of_metalloproteinase
- Tissue Inhibitor of Metalloproteinases. In: Wikidata. https://www.wikidata.org/wiki/Q4531845