Structured Summary
Abstract
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
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Classification
Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
3 entry terms
- TIMP-2
- Metalloproteinase-2 Tissue Inhibitor
- Tissue Inhibitor of Metalloproteinase 2
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997
MeSH Record
Previous Indexing
- Neoplasm Proteins (1989-1993)
- Proteins (1990-1997)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Tissue Inhibitor of Metalloproteinase-2. Medical Subject Headings (MeSH). 2026. Unique ID D019716. http://id.nlm.nih.gov/mesh/2026/D019716
- Tissue Inhibitor of Metalloproteinase-2. In: Wikidata. https://www.wikidata.org/wiki/Q24719803