Structured Summary
Abstract
A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT.
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Synonyms
4 entry terms
- TIAM-1 Protein
- TIAM1 Protein
- T Lymphoma Invasion and Metastasis inducing Protein 1
- TIAM 1 Protein
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Guanine Nucleotide Exchange Factors (2007-2017)
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AMA Style
References
- National Library of Medicine. T-Lymphoma Invasion and Metastasis-inducing Protein 1. Medical Subject Headings (MeSH). 2026. Unique ID D000075684. http://id.nlm.nih.gov/mesh/2026/D000075684
- T-Lymphoma Invasion and Metastasis-inducing Protein 1. In: Wikidata. https://www.wikidata.org/wiki/Q24782468