Phenomena and Processes

Pleckstrin Homology Domains

Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.

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See Also

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Synonyms

9 entry terms
  • PH Domain
  • PH Domains
  • Pleckstrin Homology Domain
  • Domain, PH
  • Domain, Pleckstrin Homology
  • Domains, PH
  • Domains, Pleckstrin Homology
  • Homology Domain, Pleckstrin
  • Homology Domains, Pleckstrin

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Protein Structure, Tertiary (1994-2016)

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.469w

AMA Style

References

  1. National Library of Medicine. Pleckstrin Homology Domains. Medical Subject Headings (MeSH). 2026. Unique ID D000070539. http://id.nlm.nih.gov/mesh/2026/D000070539
  2. Pleckstrin Homology Domains. In: Wikipedia. https://en.wikipedia.org/wiki/Pleckstrin_homology_domain
  3. Pleckstrin Homology Domains. In: Wikidata. https://www.wikidata.org/wiki/Q24776397