Phenomena and Processes

PDZ Domains

Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.

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Synonyms

25 entry terms
  • DHR Domains
  • DLG Homology Repeats Domains
  • GLGF Repeats Domains
  • PDZ Interaction Domains
  • PSD95-DLG-ZO1 Domains
  • DHR Domain
  • Domain, DHR
  • Domain, GLGF Repeats
  • Domain, PDZ
  • Domain, PDZ Interaction
  • Domain, PSD95-DLG-ZO1
  • Domains, DHR
  • Domains, GLGF Repeats
  • Domains, PDZ
  • Domains, PDZ Interaction
  • Domains, PSD95-DLG-ZO1
  • GLGF Repeats Domain
  • Interaction Domain, PDZ
  • Interaction Domains, PDZ
  • PDZ Domain
  • PDZ Interaction Domain
  • PSD95 DLG ZO1 Domains
  • PSD95-DLG-ZO1 Domain
  • Repeats Domain, GLGF
  • Repeats Domains, GLGF

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2008

MeSH Hierarchy

Tree Number

  1. G02.111.570.820w.709.275.750w.500.500w

AMA Style

References

  1. National Library of Medicine. PDZ Domains. Medical Subject Headings (MeSH). 2026. Unique ID D054731. http://id.nlm.nih.gov/mesh/2026/D054731
  2. PDZ Domains. In: Wikipedia. https://en.wikipedia.org/wiki/PDZ_domain
  3. PDZ Domains. In: Wikidata. https://www.wikidata.org/wiki/Q24721050