Chemicals and Drugs

Sulfamethoxazole Drug Combination Trimethoprim

A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.

Chemical Identity

Chemical Information

Molecular Formula
C24H29N7O6S
Molecular Weight
543.6 g/mol
CAS Registry No.
8064-90-2
IUPAC Name
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
InChIKey
WZRJTRPJURQBRM-UHFFFAOYSA-N
SMILES
CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N.COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
MeSH Unique ID
D015662
Source
PubChem CID 358641

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

38 entry terms
  • Centran
  • Centrin
  • Co-Trimoxazole
  • Cotrimoxazole
  • Eslectin
  • Insozalin
  • Sulfamethoxazole-Trimethoprim Combination
  • TMP SMX
  • TMP-SMX
  • Trimedin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim-Sulfamethoxazole
  • Trimethoprim-Sulfamethoxazole Combination
  • Trimezole
  • Co Trimoxazole
  • Sulfamethoxazole Trimethoprim Combination
  • Trimethoprim Sulfamethoxazole
  • Trimethoprim Sulfamethoxazole Combination
  • Abactrim
  • Bactifor
  • Bactrim
  • Biseptol
  • Biseptol-480
  • Drylin
  • Eusaprim
  • Kepinol
  • Kepinol Forte
  • Lescot
  • Metomide
  • Oriprim
  • Septra
  • Septrin
  • Sulprim
  • Sumetrolim
  • Trimethoprimsulfa
  • Trimosulfa
  • Biseptol 480
  • Biseptol480

MeSH Record

Aspects Covered

24 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1990)

MeSH Record

Previous Indexing

  • Drug Combinations (1971-1989)
  • Sulfamethoxazole (1966-1989)
  • Trimethoprim (1972-1989)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.884w.060.300w.500w
  2. D02w.065w.884w.725.867w.500w
  3. D02w.092w.146.807.867w.500w
  4. D02w.455w.426w.559w.389.085.300w.500w
  5. D02w.886w.590w.700w.090.300w.500w
  6. D02w.886w.590w.700w.725.867w.500w
  7. D03w.383.742.906w.500w
  8. D26.310w.875w

AMA Style

References

  1. National Library of Medicine. Sulfamethoxazole Drug Combination Trimethoprim. Medical Subject Headings (MeSH). 2026. Unique ID D015662. http://id.nlm.nih.gov/mesh/2026/D015662
  2. Sulfamethoxazole Drug Combination Trimethoprim. In: Wikipedia. https://en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole
  3. Sulfamethoxazole Drug Combination Trimethoprim. In: Wikidata. https://www.wikidata.org/wiki/Q898623
  4. Sulfamethoxazole Drug Combination Trimethoprim. In: PubChem Compound. CID 358641. https://pubchem.ncbi.nlm.nih.gov/compound/358641