Chemicals and Drugs

Trimethoprim

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.

Chemical Identity

Chemical Information

Molecular Formula
C14H18N4O3
Molecular Weight
290.32 g/mol
CAS Registry No.
738-70-5
IUPAC Name
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
InChIKey
IEDVJHCEMCRBQM-UHFFFAOYSA-N
SMILES
COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
MeSH Unique ID
D014295
Source
PubChem CID 5578

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • Proloprim
  • Trimpex

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria

MeSH Record

History Note

1974 (1972)

MeSH Record

Previous Indexing

  • Anti-Infective Agents (1966-1971)
  • Folic Acid Antagonists (1966-1971)
  • Pyrimidines (1966-1971)

MeSH Hierarchy

Tree Number

  1. D03w.383.742.906w

MeSH Record

NLM Classification

QV 256

AMA Style

References

  1. National Library of Medicine. Trimethoprim. Medical Subject Headings (MeSH). 2026. Unique ID D014295. http://id.nlm.nih.gov/mesh/2026/D014295
  2. Trimethoprim. In: Wikipedia. https://en.wikipedia.org/wiki/Trimethoprim
  3. Trimethoprim. In: Wikidata. https://www.wikidata.org/wiki/Q422665
  4. Trimethoprim. In: PubChem Compound. CID 5578. https://pubchem.ncbi.nlm.nih.gov/compound/5578