Chemicals and Drugs

Subfamily B ATP Binding Cassette Transporter

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to ATP-BINDING CASSETTE, SUB-FAMILY C PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • ATP Binding Cassette Transporter, Sub-Family B
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP-Binding Cassette, Sub-Family B Proteins
  • Multidrug Resistance Proteins
  • P-Glycoproteins
  • ATP Binding Cassette Transporter, Sub Family B
  • ATP Binding Cassette, Sub Family B Proteins
  • P Glycoproteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available

MeSH Record

History Note

2019 (1999); use P-GLYCOPROTEIN 1995-1998

MeSH Record

Previous Indexing

  • Glycoproteins (1980-1987)
  • Membrane Glycoproteins (1989-1994)
  • Membrane Proteins (1980-1988)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.020w.400
  2. D12.776w.157w.530w.100w.075
  3. D12.776w.157w.530w.450w.074.500w.500.250
  4. D12.776w.395w.550w.020w.400
  5. D12.776w.543w.550w.192w.400
  6. D12.776w.543w.585w.100w.200
  7. D12.776w.543w.585w.450w.074.500w.500.250

AMA Style

References

  1. National Library of Medicine. Subfamily B ATP Binding Cassette Transporter. Medical Subject Headings (MeSH). 2026. Unique ID D018435. http://id.nlm.nih.gov/mesh/2026/D018435
  2. Subfamily B ATP Binding Cassette Transporter. In: Wikidata. https://www.wikidata.org/wiki/Q99755548