Chemicals and Drugs

Subfamily B Member 1 ATP Binding Cassette Transporter

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

21 entry terms
  • ABCB1 Protein
  • ATP Binding Cassette Transporter, Sub-Family B, Member 1
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette, Sub-Family B, Member 1
  • CD243 Antigen
  • MDR1 Protein
  • Multidrug Resistance Protein 1
  • P-Glycoprotein
  • PGY-1 Protein
  • Antigen, CD243
  • P Glycoprotein
  • PGY 1 Protein
  • ATP-Dependent Translocase ABCB1
  • MDR1B Protein
  • P-Glycoprotein 1
  • 1, P-Glycoprotein
  • ABCB1, ATP-Dependent Translocase
  • ATP Dependent Translocase ABCB1
  • P Glycoprotein 1
  • Protein, MDR1B
  • Translocase ABCB1, ATP-Dependent

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available

MeSH Record

History Note

2019 (1995)

MeSH Record

Previous Indexing

  • P-Glycoprotein (1995-1998)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.020w.400.153w
  2. D12.776w.157w.530w.100w.075.063w
  3. D12.776w.157w.530w.450w.074.500w.500.250.125w
  4. D12.776w.395w.550w.020w.400.153w
  5. D12.776w.543w.550w.192w.400.153w
  6. D12.776w.543w.585w.100w.200.125w
  7. D12.776w.543w.585w.450w.074.500w.500.250.125w

AMA Style

References

  1. National Library of Medicine. Subfamily B Member 1 ATP Binding Cassette Transporter. Medical Subject Headings (MeSH). 2026. Unique ID D020168. http://id.nlm.nih.gov/mesh/2026/D020168
  2. Subfamily B Member 1 ATP Binding Cassette Transporter. In: Wikipedia. https://en.wikipedia.org/wiki/P-glycoprotein
  3. Subfamily B Member 1 ATP Binding Cassette Transporter. In: Wikidata. https://www.wikidata.org/wiki/Q412902