Chemicals and Drugs

Sub-Family C Proteins ATP-Binding Cassette

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

9 entry terms
  • ATP-Binding Cassette, Sub-Family C Proteins
  • Multidrug Resistance-Associated Protein
  • Multidrug Resistance-Associated Proteins
  • Multispecific Organic Anion Transport Proteins
  • Multispecific Organic Anion Transporter
  • ATP Binding Cassette, Sub Family C Proteins
  • Multidrug Resistance Associated Protein
  • Multidrug Resistance Associated Proteins
  • Resistance-Associated Protein, Multidrug

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2026(2002); use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001

MeSH Record

Previous Indexing

  • P-Glycoprotein (1987-2001)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.100w.304
  2. D12.776w.157w.530w.450w.074.500w.500.500
  3. D12.776w.543w.585w.100w.304
  4. D12.776w.543w.585w.450w.074.500w.500.500

AMA Style

References

  1. National Library of Medicine. Sub-Family C Proteins ATP-Binding Cassette. Medical Subject Headings (MeSH). 2026. Unique ID D027425. http://id.nlm.nih.gov/mesh/2026/D027425
  2. Sub-Family C Proteins ATP-Binding Cassette. In: Wikidata. https://www.wikidata.org/wiki/Q24772295