Structured Summary
Abstract
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
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Synonyms
17 entry terms
- 21-Hydroxylase
- Cytochrome P-450 21-Hydroxylase
- Cytochrome P-450 CYP21
- Cytochrome P-450 c21
- Cytochrome P-450(c-21)
- Cytochrome P450c21
- Progesterone 21-Hydroxylase
- Steroid 21-Monooxygenase
- Steroid-21-Hydroxylase
- 21 Hydroxylase
- Cytochrome P 450 21 Hydroxylase
- Cytochrome P 450 CYP21
- Cytochrome P 450 c21
- P-450 c21, Cytochrome
- Progesterone 21 Hydroxylase
- Steroid 21 Hydroxylase
- Steroid 21 Monooxygenase
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2003 (1978)
MeSH Record
Previous Indexing
- Steroid Hydroxylases (1973-1977)
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AMA Style
References
- National Library of Medicine. Steroid 21-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D013255. http://id.nlm.nih.gov/mesh/2026/D013255
- Steroid 21-Hydroxylase. In: Wikipedia. https://en.wikipedia.org/wiki/21-Hydroxylase
- Steroid 21-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q21110736