Structured Summary
Abstract
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
MeSH Record
Classification
Broader headings
Narrower headings
- Aryl Hydrocarbon Hydroxylases
- Camphor 5-Monooxygenase
- Cytochrome P-450 CYP2J2
- Cytochrome P450 Family 1
- Cytochrome P450 Family 11
- Cytochrome P450 Family 12
- Cytochrome P450 Family 17
- Cytochrome P450 Family 19
- Cytochrome P450 Family 2
- Cytochrome P450 Family 21
- Cytochrome P450 Family 24
- Cytochrome P450 Family 26
- Cytochrome P450 Family 27
- Cytochrome P450 Family 3
- Cytochrome P450 Family 4
- Cytochrome P450 Family 46
- Cytochrome P450 Family 51
- Cytochrome P450 Family 6
- Cytochrome P450 Family 7
- Cytochrome P450 Family 8
- Steroid Hydroxylases
- Trans-Cinnamate 4-Monooxygenase
Related Concepts
Knowledge Graph
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MeSH Record
Synonyms
41 entry terms
- CYP450 Family
- CYP450 Superfamily
- Cytochrome P-450
- Cytochrome P-450 Enzyme
- Cytochrome P-450 Enzymes
- Cytochrome P-450 Families
- Cytochrome P-450 Superfamily
- Cytochrome P450
- Cytochrome P450 Superfamily
- Cytochrome p450 Families
- P-450 Enzyme
- P-450 Enzymes
- P450 Enzyme
- P450 Enzymes
- Cytochrome P 450
- Cytochrome P 450 Enzyme
- Cytochrome P 450 Enzyme System
- Cytochrome P 450 Enzymes
- Cytochrome P 450 Families
- Cytochrome P 450 Superfamily
- Enzyme, Cytochrome P-450
- Enzyme, P-450
- Enzyme, P450
- Enzymes, Cytochrome P-450
- Enzymes, P-450
- Enzymes, P450
- P 450 Enzyme
- P 450 Enzymes
- P-450 Enzyme, Cytochrome
- P-450 Enzymes, Cytochrome
- Superfamily, CYP450
- Superfamily, Cytochrome P-450
- Superfamily, Cytochrome P450
- Cytochrome P-450 Monooxygenase
- Cytochrome P-450 Oxygenase
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Cytochrome P 450 Monooxygenase
- Cytochrome P 450 Oxygenase
- Monooxygenase, Cytochrome P-450
- Monooxygenase, Cytochrome P-450-Dependent
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
general or unspecified; prefer specific cytochrome P-450's
MeSH Record
History Note
73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
MeSH Record
Previous Indexing
- Cytochromes (1966-1972)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Cytochrome P-450 Enzyme System. Medical Subject Headings (MeSH). 2026. Unique ID D003577. http://id.nlm.nih.gov/mesh/2026/D003577
- Cytochrome P-450 Enzyme System. In: Wikipedia. https://en.wikipedia.org/wiki/Cytochrome_P450
- Cytochrome P-450 Enzyme System. In: Wikidata. https://www.wikidata.org/wiki/Q407693