Chemicals and Drugs

Steroid 17-alpha-Hydroxylase

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

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Synonyms

34 entry terms
  • 17 alpha-Hydroxylase
  • 17 alpha-Hydroxylase Cytochrome P-450
  • 17,20-Desmolase
  • 17,20-Lyase
  • CYP17
  • Cytochrome P-450(17 alpha)
  • Cytochrome P-450(17-alpha)
  • Cytochrome P450(17 alpha)
  • P450(c17)
  • Steroid 17 alpha-Hydroxylase
  • Steroid 17 alpha-Monooxygenase
  • Steroid 17-Hydroxylase
  • Steroid 17-Monooxygenase
  • Steroid-17-Hydroxylase
  • 17 alpha Hydroxylase
  • 17 alpha Hydroxylase Cytochrome P 450
  • 17 alpha-Hydroxylase, Steroid
  • 17 alpha-Monooxygenase, Steroid
  • 17,20 Desmolase
  • 17,20 Lyase
  • 17-Hydroxylase, Steroid
  • 17-Monooxygenase, Steroid
  • 17-alpha-Hydroxylase, Steroid
  • Steroid 17 Hydroxylase
  • Steroid 17 Monooxygenase
  • Steroid 17 alpha Hydroxylase
  • Steroid 17 alpha Monooxygenase
  • alpha-Monooxygenase, Steroid 17
  • 17 alpha-Hydroxyprogesterone Aldolase
  • Hydroxyprogesterone Aldolase
  • 17 alpha Hydroxyprogesterone Aldolase
  • Aldolase, 17 alpha-Hydroxyprogesterone
  • Aldolase, Hydroxyprogesterone
  • alpha-Hydroxyprogesterone Aldolase, 17

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003 (1978)

MeSH Record

Previous Indexing

  • Steroid Hydroxylases (1973-1977)

MeSH Hierarchy

Tree Numbers

  1. D08.244w.453w.487.500w
  2. D08.244w.453w.915w.748w
  3. D08.811w.682w.690w.708.170w.444.500w
  4. D08.811w.682w.690w.708.170w.915w.748w
  5. D12.776w.422w.220w.453w.487.500w
  6. D12.776w.422w.220w.453w.915w.748w

AMA Style

References

  1. National Library of Medicine. Steroid 17-alpha-Hydroxylase. Medical Subject Headings (MeSH). 2026. Unique ID D013254. http://id.nlm.nih.gov/mesh/2026/D013254
  2. Steroid 17-alpha-Hydroxylase. In: Wikipedia. https://en.wikipedia.org/wiki/Steroid_17alpha-monooxygenase
  3. Steroid 17-alpha-Hydroxylase. In: Wikidata. https://www.wikidata.org/wiki/Q3973289