Chemicals and Drugs

Signaling Lymphocytic Activation Molecule Family

Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.

MeSH Record

Classification

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MeSH Record

Synonyms

5 entry terms
  • SLAM Family Receptors
  • SLAMF Receptors
  • Signaling Lymphocytic Activation Molecule Family Receptors
  • Signaling Lymphocytic Activation Molecule Receptors
  • Signaling Lymphocytic Activation Molecules

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Antigens, CD (1997-2016)
  • Receptors, Cell Surface (1997-2016)

MeSH Hierarchy

Tree Numbers

  1. D09w.400w.430w.890w.736w
  2. D12.776w.395w.550w.736w
  3. D12.776w.543w.550w.746w
  4. D12.776w.543w.750w.705w.970w

AMA Style

References

  1. National Library of Medicine. Signaling Lymphocytic Activation Molecule Family. Medical Subject Headings (MeSH). 2026. Unique ID D000071176. http://id.nlm.nih.gov/mesh/2026/D000071176
  2. Signaling Lymphocytic Activation Molecule Family. In: Wikipedia. https://en.wikipedia.org/wiki/Signaling_lymphocytic_activation_molecule
  3. Signaling Lymphocytic Activation Molecule Family. In: Wikidata. https://www.wikidata.org/wiki/Q7512771