Chemicals and Drugs

STAT Transcription Factors

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

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MeSH Record

Synonyms

2 entry terms
  • STAT (Signal Transducers and Activators of Transcription) Proteins
  • Transcription Factors, STAT

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

general; prefer specifics

MeSH Record

History Note

2006

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.342w
  2. D12.776w.157w.057w.186w
  3. D12.776w.476.024w.430w
  4. D12.776w.930w.840w

AMA Style

References

  1. National Library of Medicine. STAT Transcription Factors. Medical Subject Headings (MeSH). 2026. Unique ID D050791. http://id.nlm.nih.gov/mesh/2026/D050791
  2. STAT Transcription Factors. In: Wikipedia. https://en.wikipedia.org/wiki/STAT_protein
  3. STAT Transcription Factors. In: Wikidata. https://www.wikidata.org/wiki/Q419333