Chemicals and Drugs

Ribosomal Protein S6 Kinases

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.

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Synonyms

4 entry terms
  • Ribosomal Protein S6 Kinase
  • S6 Kinase
  • S6-H4 Kinase
  • S6 H4 Kinase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997

MeSH Record

Previous Indexing

  • Protein Kinases (1985-1992)
  • Protein-Serine-Threonine Kinases (1993-1997)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.862w
  2. D12.776w.476.563w.862w

AMA Style

References

  1. National Library of Medicine. Ribosomal Protein S6 Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D019893. http://id.nlm.nih.gov/mesh/2026/D019893
  2. Ribosomal Protein S6 Kinases. In: Wikipedia. https://en.wikipedia.org/wiki/Ribosomal_s6_kinase
  3. Ribosomal Protein S6 Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q24778284