Chemicals and Drugs

70-kDa Ribosomal Protein S6 Kinases

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • Ribosomal Protein S6 Kinases, 70-kDa
  • p70 S6 Kinase
  • p70s6k
  • Ribosomal Protein S6 Kinases, 70 kDa
  • S6 Kinase, p70

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2005(2003); for P70 S6 KINASE & P70S6K use RIBOSOMAL PROTEIN S6 KINASES 1998-2002

MeSH Record

Previous Indexing

  • Ribosomal Protein S6 Kinases (1990-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.862w.249
  2. D12.776w.476.563w.862w.249

AMA Style

References

  1. National Library of Medicine. 70-kDa Ribosomal Protein S6 Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D038762. http://id.nlm.nih.gov/mesh/2026/D038762
  2. 70-kDa Ribosomal Protein S6 Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q77196986