Chemicals and Drugs

90-kDa Ribosomal Protein S6 Kinases

A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

15 entry terms
  • MAP-Kinase-Activated Kinase 1
  • MAP-Kinase-Activated Protein Kinase 1
  • MAPKAP Kinase-1
  • MAPKAP-K1
  • MAPKAPK1
  • Ribosomal Protein S6 Kinase, 90-kDa
  • Ribosomal Protein S6 Kinases, 90-kDa
  • p90 Ribosomal S6 Kinase
  • p90(rsk)
  • pp90(rsk)
  • MAP Kinase Activated Kinase 1
  • MAP Kinase Activated Protein Kinase 1
  • MAPKAP Kinase 1
  • Ribosomal Protein S6 Kinase, 90 kDa
  • Ribosomal Protein S6 Kinases, 90 kDa

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2005(2002); for PP90(RSK) & PP90(RSK) use RIBOSOMAL PROTEIN S6 KINASES 1998-2002

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (1993-1997)
  • Ribosomal Protein S6 Kinase (1998-2002)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.862w.500
  2. D12.776w.476.563w.862w.500

AMA Style

References

  1. National Library of Medicine. 90-kDa Ribosomal Protein S6 Kinases. Medical Subject Headings (MeSH). 2026. Unique ID D038744. http://id.nlm.nih.gov/mesh/2026/D038744
  2. 90-kDa Ribosomal Protein S6 Kinases. In: Wikidata. https://www.wikidata.org/wiki/Q77197509