Phenomena and Processes

RING Finger Domains

A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.

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Synonyms

4 entry terms
  • RING Finger Motifs
  • Domains, RING Finger
  • RING Finger Domain
  • RING Finger Motif

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Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2008

MeSH Hierarchy

Tree Numbers

  1. G02.111.570.820w.709.275.500.985w.500w
  2. G02.111.570.820w.709.275.750w.500.625w

AMA Style

References

  1. National Library of Medicine. RING Finger Domains. Medical Subject Headings (MeSH). 2026. Unique ID D054829. http://id.nlm.nih.gov/mesh/2026/D054829
  2. RING Finger Domains. In: Wikipedia. https://en.wikipedia.org/wiki/RING_finger_domain
  3. RING Finger Domains. In: Wikidata. https://www.wikidata.org/wiki/Q24788168