Chemicals and Drugs

Tripartite Motif-Containing Protein 28

A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

2 entry terms
  • TRIM28 Protein
  • Tripartite Motif Containing Protein 28

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Repressor Proteins (2004-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.464w.938.750.782
  2. D12.776w.260w.703.675
  3. D12.776w.930w.780.911
  4. D12.776w.934w.875

AMA Style

References

  1. National Library of Medicine. Tripartite Motif-Containing Protein 28. Medical Subject Headings (MeSH). 2026. Unique ID D000076183. http://id.nlm.nih.gov/mesh/2026/D000076183
  2. Tripartite Motif-Containing Protein 28. In: Wikidata. https://www.wikidata.org/wiki/Q21102214