Phenomena and Processes

Protein Prenylation

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl diphosphate or geranylgeranyl diphosphate, are derived from the same biochemical pathway that produces cholesterol.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

9 entry terms
  • Prenylation, Protein
  • Post-Translational Isoprenylation
  • Protein Farnesylation
  • Protein Geranylgeranylation
  • Protein Isoprenylation
  • Protein Polyisoprenylation
  • Farnesylation, Protein
  • Geranylgeranylation, Protein
  • Polyisoprenylation, Protein

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2008(1993)

MeSH Record

Previous Indexing

  • Protein Processing, Post-Translational (1987-1992)

MeSH Hierarchy

Tree Numbers

  1. G02.111.660.871w.790.600w.400
  2. G02.111.672w.500
  3. G02.111.691.600w.400
  4. G03w.734.871w.790.600w.400
  5. G03w.804w.500
  6. G05.308w.670.600w.400

AMA Style

References

  1. National Library of Medicine. Protein Prenylation. Medical Subject Headings (MeSH). 2026. Unique ID D017368. http://id.nlm.nih.gov/mesh/2026/D017368
  2. Protein Prenylation. In: Wikidata. https://www.wikidata.org/wiki/Q21126055