Chemicals and Drugs

Neuropilins

Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.

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Synonyms

1 entry terms
  • Neuropilin

MeSH Record

Aspects Covered

19 allowable subheadings

Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002

MeSH Record

Previous Indexing

  • Nerve Tissue Proteins (1998-2002)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.750w.590w

AMA Style

References

  1. National Library of Medicine. Neuropilins. Medical Subject Headings (MeSH). 2026. Unique ID D039921. http://id.nlm.nih.gov/mesh/2026/D039921
  2. Neuropilins. In: Wikipedia. https://en.wikipedia.org/wiki/Neuropilin
  3. Neuropilins. In: Wikidata. https://www.wikidata.org/wiki/Q1188971