Structured Summary
Abstract
A dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and AXONAL GUIDANCE. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS; their binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
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Broader headings
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Synonyms
9 entry terms
- A5 Antigen
- NRP1 Protein
- Npn-1 Protein
- Sema III Receptor
- Semaphorin III Receptor
- Antigen, A5
- Neuropilin 1
- Npn 1 Protein
- Receptor, Sema III
MeSH Record
Aspects Covered
19 allowable subheadings
Indexed with the subheadings administration & dosage, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.
MeSH Record
History Note
2003; use NEUROPILIN-1 (NM) 1991-2002
MeSH Record
Previous Indexing
- Nerve Tissue Proteins (1991-2002)
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AMA Style
References
- National Library of Medicine. Neuropilin-1. Medical Subject Headings (MeSH). 2026. Unique ID D039942. http://id.nlm.nih.gov/mesh/2026/D039942
- Neuropilin-1. In: Wikidata. https://www.wikidata.org/wiki/Q24723019