Diseases

Multiple Endocrine Neoplasia Type 2a

A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

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Classification

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MeSH Record

Synonyms

19 entry terms
  • MEA 2a
  • MEA II
  • MEA IIa
  • MEN 2
  • MEN 2a
  • MEN II
  • MEN IIa
  • MEN-2A Syndrome
  • MEN2a
  • Multiple Endocrine Neoplasia Type 2
  • Multiple Endocrine Neoplasia, Type IIa
  • Multiple Endocrine Neoplasms Type 2a
  • Neoplasia, Multiple Endocrine Type 2a
  • Neoplasms, Multiple Endocrine Type 2a
  • Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
  • Sipple Syndrome
  • MEN 2A Syndrome
  • MEN-2A Syndromes
  • Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent

MeSH Record

History Note

95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94

MeSH Record

Previous Indexing

  • Multiple Endocrine Neoplasia (1966-1994)

MeSH Hierarchy

Tree Numbers

  1. C04w.588.322w.400w.505w
  2. C04w.651.600w.505w
  3. C04w.700w.630w.505w
  4. C16w.320w.700w.630w.505w
  5. C19w.344w.400w.505w

AMA Style

References

  1. National Library of Medicine. Multiple Endocrine Neoplasia Type 2a. Medical Subject Headings (MeSH). 2026. Unique ID D018813. http://id.nlm.nih.gov/mesh/2026/D018813
  2. Multiple Endocrine Neoplasia Type 2a. In: Wikipedia. https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2
  3. Multiple Endocrine Neoplasia Type 2a. In: Wikidata. https://www.wikidata.org/wiki/Q604075