Diseases

Hereditary Neoplastic Syndromes

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.

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Classification

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MeSH Record

Synonyms

11 entry terms
  • Cancer Syndromes, Hereditary
  • Hereditary Cancer Syndromes
  • Neoplastic Syndromes, Hereditary
  • Cancer Syndrome, Hereditary
  • Hereditary Cancer Syndrome
  • Hereditary Neoplastic Syndrome
  • Neoplastic Syndrome, Hereditary
  • Syndrome, Hereditary Cancer
  • Syndrome, Hereditary Neoplastic
  • Syndromes, Hereditary Cancer
  • Syndromes, Hereditary Neoplastic

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate with specific hereditary organ/neoplasm term or specific hereditary histological type

MeSH Record

History Note

87

MeSH Hierarchy

Tree Numbers

  1. C04w.700w
  2. C16w.320w.700w

MeSH Record

NLM Classification

QZ 210

AMA Style

References

  1. National Library of Medicine. Hereditary Neoplastic Syndromes. Medical Subject Headings (MeSH). 2026. Unique ID D009386. http://id.nlm.nih.gov/mesh/2026/D009386
  2. Hereditary Neoplastic Syndromes. In: Wikipedia. https://en.wikipedia.org/wiki/Hereditary_cancer_syndrome
  3. Hereditary Neoplastic Syndromes. In: Wikidata. https://www.wikidata.org/wiki/Q1348398