Chemicals and Drugs

Initiator Codon

A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.

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Classification

Broader headings

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Synonyms

11 entry terms
  • Codon, Initiation
  • Codon, Initiator
  • Codon, Start
  • Start Codon
  • Codons, Initiation
  • Codons, Initiator
  • Codons, Start
  • Initiation Codon
  • Initiation Codons
  • Initiator Codons
  • Start Codons

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Codon (1975-1994)

MeSH Hierarchy

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References

  1. National Library of Medicine. Initiator Codon. Medical Subject Headings (MeSH). 2026. Unique ID D018387. http://id.nlm.nih.gov/mesh/2026/D018387
  2. Initiator Codon. In: Wikipedia. https://en.wikipedia.org/wiki/Start_codon
  3. Initiator Codon. In: Wikidata. https://www.wikidata.org/wiki/Q1854186