Structured Summary
Abstract
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
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Synonyms
1 entry terms
- Caspases, Initiator
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2007
MeSH Record
Previous Indexing
- Caspases (1999-2006)
- Cysteine Proteinases (1997-1998)
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References
- National Library of Medicine. Initiator Caspases. Medical Subject Headings (MeSH). 2026. Unique ID D053471. http://id.nlm.nih.gov/mesh/2026/D053471
- Initiator Caspases. In: Wikidata. https://www.wikidata.org/wiki/Q76852493