Chemicals and Drugs

Immunoglobulin Variable Region

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

33 entry terms
  • Ig Variable Region
  • Immunoglobulin V
  • Variable Region, Ig
  • Variable Region, Immunoglobulin
  • Ig Variable Regions
  • Immunoglobulin Variable Regions
  • Regions, Immunoglobulin Variable
  • Variable Regions, Ig
  • Variable Regions, Immunoglobulin
  • Framework Region, Immunoglobulin
  • Fv Antibody Fragments
  • Fv Fragments
  • Ig Framework Region
  • Immunoglobulin Framework Region
  • Immunoglobulin Fv Fragments
  • Antibody Fragment, Fv
  • Antibody Fragments, Fv
  • Fragment, Fv
  • Fragment, Fv Antibody
  • Fragment, Immunoglobulin Fv
  • Fragments, Fv
  • Fragments, Fv Antibody
  • Fragments, Immunoglobulin Fv
  • Framework Region, Ig
  • Framework Regions, Ig
  • Framework Regions, Immunoglobulin
  • Fv Antibody Fragment
  • Fv Fragment
  • Fv Fragment, Immunoglobulin
  • Fv Fragments, Immunoglobulin
  • Ig Framework Regions
  • Immunoglobulin Framework Regions
  • Immunoglobulin Fv Fragment

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

84(77); was see under BINDING SITES, ANTIBODY 1977-83

MeSH Record

Previous Indexing

  • Antigenic Determinants (1972-1976)
  • Binding Sites, Antibody (1973-1976)
  • Immunoglobulin Fragments (1973-1976)
  • Immunoglobulins, Fab (1973-1976)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.541.500.650w.500
  2. D12.776w.124w.486.485.680.650w.500
  3. D12.776w.124w.486.485.797
  4. D12.776w.124w.790.651.680.650w.500
  5. D12.776w.124w.790.651.797
  6. D12.776w.377w.715.548.680.650w.500
  7. D12.776w.377w.715.548.797
  8. G02.111.570.060w.425

AMA Style

References

  1. National Library of Medicine. Immunoglobulin Variable Region. Medical Subject Headings (MeSH). 2026. Unique ID D007135. http://id.nlm.nih.gov/mesh/2026/D007135
  2. Immunoglobulin Variable Region. In: Wikidata. https://www.wikidata.org/wiki/Q58510722